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Pioneering Cell-Free Regenerative Medicine

RheeGen® is the world’s first topical, transdermal regenerative therapy based on cell-free bioactive biomolecules derived from human Mesenchymal Stem Cells (MSCs). By delivering these powerful signaling factors through the skin—without using live cells or injections—RheeGen® represents a groundbreaking leap in regenerative wellness.

Press the “Press” button to view articles featuring Dr. Rhee discussing the innovation behind RheeGen®

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RheeGen® Compared to the Market

Current Market:

$4,500-$15,000 per visit

RheeGen®:

90% more cost-effective 

Current Market:

Need to be administered by Medical doctor or nurse practitioner

RheeGen®:

Topical self application

Current Market:

Risk of infection + 2-4 weeks of downtime + Risk of Tumor

RheeGen®:

Low risk of infection + no downtime! + No Risk of Tumor Formation

As Seen On

Testimonials & Press

Dr. Tommy Rhee Reimagines Regenerative Medicine with a Topical Twist
RheeGen®'s Topical Stem Cell Therapy Pioneers Future of Regenerative Medicine
RheeGen®'s Topical Stem Cell Therapy Pioneers Future of Regenerative Medicine
RheeGen®'s Topical Stem Cell Therapy Pioneers Future of Regenerative Medicine
RheeGen®’s Topical Stem Cell Therapy Pioneers Future of Regenerative Medicine
Dr. Thomas Rhee, Sports Chiropractor and Creator/CEO of RheeGen®, Discusses Regenerative Sports Medicine
Redefining Recovery: Dr. Tommy Rhee’s Bold Vision for the Future of Healing Through Topical Stem Cell Therapy
Reimagining Recovery: Dr. Tommy Rhee's Groundbreaking Vision for Healing with Topical Stem Cell Therapy
Revolutionizing Recovery: Dr. Tommy Rhee Unveils a New Era in Regenerative Healing
Healing Without the Hurt: A New Era in Stem Cell Therapy
Healing Without the Hurt: The Rise of Needleless Stem Cell Therapy
Dr. Tommy Rhee Redefines Recovery with New Book on Topical Stem Cell Therapy
The Next Chapter in Healing: Dr. Tommy Rhee and the Rise of Topical Stem Cell Therapy
Why Topical Stem Cell Therapy Can Change the Way We Heal
How Topical Stem Cell Therapy Is Changing the Way We Recover
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Topical Stem Cell Therapy EXPLAINED w/ Dr. Tommy Rhee
Dr. Tommy Rhee :: Revolutionizing Stem Cell Therapy
Stem Cell Secrets You Need to Know for Brain Health - Dr. Tommy Rhee
The Devon Taylor Podcast- The Future of Regenerative Medicine W/ Dr. Tommy Rhee
Healing Without Needles: The Benefits of Topical Stem Cell Therapy
The Blueprint: Dr. Tommy Rhee Stem Cell Secrets
Confidence Through Health Podcast: Breakthroughs in Stem Cell Therapy w/ Dr. Tommy Rhee
Criminal Justice Evolution Podcast: The Power of Stem Cells with Dr. Tommy Rhee
Unlocking the Future of Regenerative Medicine with Dr. Tommy Rhee
Rising Above Obstacles with Dr. Tommy Rhee
people doing squats outside
Young woman having massage treatment in health centre.
RheeGen bottles in packaging

About Us

A New Era in Regenerative Medicine — Cell-Free, Topical, and Transformative

RheeGen® represents a revolutionary leap in regenerative science — the first cell-free, topical regenerative technology designed to make advanced healing safe, accessible, and affordable.
While traditional regenerative therapies often rely on costly injections or live cell procedures, RheeGen® uses bioactive biomolecules derived from human Mesenchymal Stem Cells — without the cells themselves. These molecules, including extracellular vesicles and signaling factors, are delivered transdermally to stimulate your body’s natural repair and recovery pathways.

Why RheeGen®?

  • No cells, no needles, no downtime
  • Topical, self-applied treatment — ask your provider and apply it at home
  • Fraction of the cost of injection-based therapies
  • Clinically observed benefits in reducing pain, inflammation, and discomfort — often after just one use
  • Lowest chance of tumor formation

With RheeGen®, you hold the future of cell-free regenerative medicine in your hands.

What Is Regenerative Technology?
Where to Buy

How It Works — Cell-Free Bioactive Biomolecules

Regeneration Without Cells. Relief Without Injections.
RheeGen® harnesses the power of cell-free bioactive biomolecules — the healing signals naturally secreted by human Mesenchymal Stem Cells (MSCs) — to support your body’s recovery and resilience.
Our two-part system includes:

Alpha (Morning) — formulated to activate circulation, support tissue function, and prepare the body for daily activity.
Omega (Evening) — designed to calm inflammation, promote regenerative signaling, and assist in nighttime recovery.

Together, this cell-free system delivers a non-invasive, topical solution that helps relieve discomfort and enhance joint and muscle wellness — no injections, no procedures, just breakthrough science in a cream.

Our Product

Patient Testimonials

Stories of Transformation

Real people, real results. Read heartfelt testimonials from individuals who have experienced the transformative power of our regenerative technology firsthand.


"I was very skeptical but RheeGen helped me. Reduced my nagging back and knee pain. I play golf every day. Never feel like I have to take a day off."
Mark B.
"Highly recommend! I love CrossFit and being over 40, I have more aches and pain then when I was in my 20s. I like that I can use RheeGen to help recover faster and get me back to 100%. This cream is allowing me to workout more with less recovery or injury. I feel I can push myself harder with less rest then before."
Stephanie Y.

"I have been using RheeGen® for five months after trying many different approaches to knee and shoulder problems damaged from 34 years of building and operating a Tropical Fish Farm in Florida. RheeGen® is the only product that has resulted in any significant improvement. Ten years ago my orthopedic doctor said I was eight years away from knee replacement. I tried everything from NSAIDS to an anti-inflammatory diet and physical therapy. My condition was advanced due to the long term nature of overuse. But with consistent application RheeGen® has worked. I am able to comfortably perform rigorous tasks I was unable to attempt 5 years ago."
Tom T.

Individual results may vary. This product is not intended to diagnose, treat, cure, or prevent any disease. For Professional Use Only 

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Got Questions? Reach Out To Us

info@rheegen.com
855-786-0489

Frequently Asked Questions

Find answers to common questions about Regenerative Medicine and RheeGen®

Do I need a prescription to buy RheeGen®?
While RheeGen® does not require a prescription, it is a professional use only product and can only be purchased through approved providers.
Yes, RheeGen® has a shelf life of 6 months if left at room-temperature and 12 months if refrigerated. Please refer to your kit for specific expiration date.
RheeGen® Alpha is used in the morning or before activity and will provide a thermogenic effect on the application area. RheeGen® Omega is used in the evening or after activity and will provide a cooling effect on the application area. Both products contain bioactive biomolecules.
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Revolutionize Your Wellness

Step Into the Future of Regeneration — No Cells, No Needles.

Your path to enhanced wellness begins today. Experience the transformative power of cell-free regenerative medicine with RheeGen® — a needle-free solution that supports your body’s natural recovery.

Ask your provider how RheeGen® can fit into your wellness journey.

Pioneering the Regenerative Wellness Industry.

These statements have not been evaluated by the Food and Drug Administration. Individual results may vary. This product is not intended to diagnose, treat, cure, or prevent any disease.

For Professional Use Only

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