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RheeGen® FAQ – Cell-Free Regenerative Medicine

Are the donors screened beforehand?

Yes, all donors go through extensive screening before and after the tissue is taken. For more information on your specific donor, ask your provider.

Yes, RheeGen® has a shelf life of 6 months if left at room-temperature and 12 months if refrigerated. Please refer to your kit for a specific expiration date.

Mesenchymal Stem Cells (MSCs) are multipotent cells that can be found in bone marrow, adipose tissue, dental pulp, or in the Wharton’s Jelly of umbilical cord and placenta tissue.

Cell-Free Bioactive Biomolecules are signaling molecules derived from Mesenchymal Stem Cells that support the body’s natural recovery process.

The Bioactive Biomolecule formula in RheeGen® is a cell-free formula derived from the same ingredients found in traditional regenerative technologies.

No, it is not recommended to use the product if pregnant or breastfeeding.

You can use RheeGen® Alpha or Omega up to two times per day.
RheeGen® Alpha is used in the morning or before activity and will provide a thermogenic effect on the application area. RheeGen® Omega is used in the evening or after activity and will provide a cooling effect on the application area. Both products contain cell-free bioactive biomolecules.

No, do not apply to open wounds or damaged skin.

RheeGen® Alpha and Omega were developed to be used together for maximum results.

Wash the area with soap and cool water. If the rash persists, contact your doctor.

Yes.

Consult with your doctor before using RheeGen® with oral medication.

RheeGen® is not FDA-approved as a drug or biologic. However, RheeGen® is manufactured in an FDA-registered facility and follows appropriate cosmetic and over-the-counter (OTC) regulatory guidelines depending on its use. It is labeled “For Professional Use Only” to reflect its advanced formulation and intended use under professional guidance.

“For Professional Use Only” means that RheeGen® is intended to be used or dispensed by licensed healthcare professionals. This designation helps ensure that patients receive appropriate guidance on how and where to apply the product, especially when used as part of a treatment plan for musculoskeletal support or recovery.

RheeGen® may be applied at home by patients—but only when instructed by a licensed professional. It is not a general consumer product and should be used as directed under clinical or therapeutic supervision to ensure safe and effective outcomes.

 RheeGen® is a specialized product that uses advanced ingredients—including cell-free bioactive molecules and transdermal enhancers—formulated for deeper tissue penetration. Its complexity and potential clinical applications make it better suited for professional use rather than general OTC retail at this time.

 Yes. RheeGen® is developed in accordance with FDA guidelines for products classified under cosmetic or OTC frameworks. It is manufactured in an FDA-registered facility and includes appropriate labeling and safety disclosures. However, it is not classified as a drug, biologic, or device requiring premarket approval.

RheeGen® does not require a prescription. However, due to its professional-grade formulation, it is only available through licensed providers who can determine if it is appropriate for your specific condition.

Cell-free regenerative medicine uses bioactive molecules (such as extracellular vesicles, growth factors, cytokines, and peptides) that are secreted by stem cells—without using any live cells. These molecules communicate with the body’s natural healing systems to promote tissue recovery, reduce inflammation, and support musculoskeletal wellness.

Traditional stem cell therapy involves injecting live cells, which can carry risks such as immune rejection or uncontrolled growth.
RheeGen® is a cell-free, topical alternative — it delivers only the regenerative signals from stem cells, making it safer, non-invasive, and easier to use.

No. Since RheeGen® is cell-free, it does not contain any living, replicating cells. This eliminates the risk of tumor formation that may occur in rare cases with live Mesenchymal Stem Cells (MSCs). RheeGen® delivers only non-replicating bioactive molecules that support healing — not cell division.

The bioactive molecules in RheeGen® are derived from Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs), ethically sourced from donated umbilical cord tissue. All donors are rigorously screened, and every batch is fully traceable and processed in an FDA-registered lab.

RheeGen® is manufactured in an FDA-registered lab under compliance with 21 CFR 1271 and Section 361 of the Public Health Service Act. While the product itself is not FDA-approved as a drug, its components are processed under strict regulatory oversight and quality control.

No. RheeGen® is topically applied and designed for at-home or in-office use. There are no injections, procedures, or downtime required.

RheeGen® comes in a two-part system:

Alpha – Apply in the morning or before activity for activation and circulation support.
Omega – Apply in the evening or after activity to cool, soothe, and aid recovery.

Each cream is applied directly to the area of concern — such as knees, back, shoulders, or wrists — for fast-acting regenerative support.

Many users report a noticeable difference after the first application, particularly in reduced discomfort and improved mobility. Consistent use supports long-term recovery and wellness.

Yes. RheeGen® can be safely used alongside physical therapy, chiropractic care, acupuncture, and other wellness modalities. Always consult with your healthcare provider for personalized guidance.

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Revolutionize Your Wellness

Step Into the Future of Regeneration — No Cells, No Needles.

Your path to enhanced wellness begins today. Experience the transformative power of cell-free regenerative medicine with RheeGen® — a needle-free solution that supports your body’s natural recovery.

Ask your provider how RheeGen® can fit into your wellness journey.

Pioneering the Regenerative Wellness Industry.

These statements have not been evaluated by the Food and Drug Administration. Individual results may vary. This product is not intended to diagnose, treat, cure, or prevent any disease.

For Professional Use Only

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